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Sustained release pregabalin with methylcobalamin in neuropathic pain – Video abstract 45271

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Video abstract of original research paper Sustained-release pregabalin with methylcobalamin in neuropathic pain: an Indian real-life experience published in the open access International Journal of General Medicine by Yasmin U Dongre and Onkar C Swami.\r\n\r\nIntroduction: Neuropathic pain is intense in nature and difficult to manage. Thus, the primary goal is maximum relief from pain. The aim of this study was to assess the efficacy and safety of a fixed-dose combination of sustained-release pregabalin and methylcobalamin in reducing neuropathic pain in Indian patients, in the real-life situation.\r\n\r\nMethods: This was a multicenter, prospective, open-labeled, single-arm, observational, 14-day study. Patients received fixed dose combination of 75 or 150 mg sustained-release pregabalin combined with 1500 mcg immediate release methylcobalamin, depending on the clinical requirement. Data was collected for pain reduction and other positive and negative symptoms associated with neuropathy, including hyperesthesia, paresthesia, numbness/tingling, burning sensation, muscle weakness, sleep disturbances, and impairment of movement. Pain intensity was measured on a ten-point visual analog scale (VAS) (0 represented \ »no pain,\ » and 10 represented \ »worst pain ever\ »). The safety of the drug was also evaluated throughout the study duration. Data was analyzed using appropriate statistical methods.\r\n\r\nResults: The overall reduction in mean VAS score over 14 days was 72.3%. The reduction in mean VAS score was significant as early as the first week. Both positive and negative symptoms of peripheral neuropathy were significantly improved in greater than 50% patients within the 2 weeks. Giddiness (4.7%), followed by sedation (3.6%), dizziness (2.9%), drowsiness (2.3%), and nausea (2.3%) were the most commonly observed adverse effects. The overall efficacy and tolerability was rated as good to excellent by greater than 95% of the investigators and patients.\r\n\r\nConclusion: Fixed dose combination of sustained-release pregabalin and methylcobalamin significantly reduced neuropathic pain, with significant improvement in both the positive and negative symptoms associated with neuropathy, in Indian patients and was well tolerated.\r\n\r\nRead the original research paper here: http://www.dovepress.com/sustained-release-pregabalin-with-methylcobalamin-in-neuropathic-pain–peer-reviewed-article
Commentaires:

Somashekhar pujari écrit: Studying assShabbir Khan écrit: Hindi translation.omkar singh écrit: Sir morning and evening le sakte hai pls jaldi batayeDJ Girlz écrit: Aur ager 3. Se 4 ek sath liye jaye to aiska koi side effet to nhiDJ Girlz écrit: Kis kam ke liye use hote hai yah tablet m e p r ,koi bata sakta haiDJ Girlz écrit: Sir pls hindisaniya iyub écrit: Sir i have sciatica so i want to take these tablets so how many days i have to take and i want to know whether it is painkiller and whether it will effect the kidneysweird science écrit: What the fuck is fortwinDeव् Singh écrit: Pregambalin kya koi vitamin hBHAGWA WORLD écrit: sir maine ye airf ek bar li thi kal muje bhut gande symptoms ho rhe hai please help kro doctor please ..muje sleeping disturbance ho rhi hai saans lene me b takleef he kab tak theek honge ye symptomsDr. Mozammel Hoque Sharife écrit: why colour of urine is yellow?Paramananda Mudoi écrit: satisfectoryVIVEK PANDEY écrit: My father feel very sleepness lightness in body.while he already use blood pressure drug.can he face any problem???Indu Goel écrit: kitne month or years tsk lr sakte h continues ly.BULLET PREMI OFFICIAL écrit: kya yeh neck pain ka kaam karegaSunny écrit: Thanks Swamy for your findings. Pregabalin and B12 worked wonders for my sciatica (leg pain with back pain)

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