effet du valium

2-Minute Neuroscience: Benzodiazepines

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Benzodiazepines are commonly used to treat anxiety disorders and sleep disorders. They are thought to exert their effects in the brain by acting at receptors for the neurotransmitter gamma-aminobutyric acid, or GABA. In this video, I cover the the mechanism of action for benzodiazepines.\n\nTRANSCRIPT: \n\nWelcome to 2 minute neuroscience, where I explain neuroscience topics in 2 minutes or less. In this installment I will discuss benzodiazepines.\n\nBenzodiazepines are a class of drugs named for their chemical structure that are commonly used to treat anxiety disorders and sleep-related disorders. They include well-known drugs like valium, xanax, and klonopin. There are dozens of drugs in the benzodiazepine class, but the mechanism by which they all exert their effects is thought to be similar.\n\nThe sedating and anxiety-reducing effects of benzodiazepines are believed to be attributable to the drugs’ actions at receptors for the neurotransmitter gamma-aminobutyic acid, or GABA. In particular, benzodiazepines act at a subtype of GABA receptors called the GABAa receptor; GABAa receptors that also bind benzodiazepines are sometimes called benzodiazepine receptors.\n\nWhen benzodiazepines bind, or attach, to the GABA receptor, they bind at a location separate from where GABA itself binds, and exert an influence over GABA binding. This type of action is called an allosteric effect, and in the case of benzodiazepines it results in increased action at the GABA receptor. There is not complete consensus on exactly how benzodiazepine binding affects activity at the GABA receptor but there is evidence to suggest that it increases the likelihood that GABA binding will activate the receptor and/or increases the effect that GABA has when it binds to the receptor.\n\nThat effect is to open an ion channel and allow the passage of negatively charged chloride ions into the neuron. This influx of negatively charged ions pushes the membrane potential further from zero, or hyperpolarizes it, and makes it less likely the neuron will fire an action potential. This type of neural inhibition is the basis for the effects of benzodiazepines, for by inhibiting the activity of neurons that make up networks involved with anxiety and arousal, the drugs are able to produce calming effects.\n\n\nREFERENCES:\n\nGielen MC, Lumb MJ, Smart TG. Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding. J Neurosci. 2012 Apr 25;32(17):5707-15. doi: 10.1523/JNEUROSCI.5663-11.2012.\n\nMöhler H, Fritschy JM, Rudolph U. A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8.
Commentaires:

drenthefilmmaker écrit: buy a mic please.Joseph Leppert écrit: 4 minutes of ads for a 2 minute disorder. This platform is over.Get Info écrit: I am here after watching AsurJeff Galaska écrit: Pure evil. Pharmaceutical= sorcery. NO BUENOCarte Bisbee écrit: I am now completely invincible against withdrawal. TyAdriano De Biasi écrit: What if I take benzodiazepines (I use lexotan) and drink coffee?? I also watched the video about caffeine. Thanks 🙂Aya Cheikh-Hussein écrit: So benzodiazepine binds to an allosteric site?Roy Dalumpines écrit: This is in “Eminem -Darkness” LyricsNeha Betgov écrit: This really helped.. Thank you!!:)Nicholas Skullion écrit: I’m watching this after taking one lolm4ssee écrit: I find it funny how everyone talks down benzos. Benzos are great unlike the fucking garbage -pines. And that's all the doctors prescribe these days even though you only like get the side effects with them without the actual benefit and in the long run they're jut as bad.y écrit: This medicine should be banned forever it's way more dangerous than lot's of hard illegal drugs, people with depression or too much stress take a step back and try to learn about psilocybin or N,N-Dimethyltryptamine if it's legal where you live and advise for yourself before taking any of those shitty medications…Daily Aine écrit: great video, super easy to understand.Parnian Faizi écrit: Who is here after Jordan Peterson recovered?Javier Lombardo Von – Vietinghoff Scheel écrit: dont take itChristine Morgan écrit: Note to public: You should not take benzos for longer than a week to two weeks because you can easily develop a dependency on them and it will be very difficult for most to get off. They are great for on the spot anxiety busters like before a medical procedure or a panic attack, but I would highly caution against further use. They are a nightmare to get off, for so many. There are people who stop taking them and are fine, but you don't want to risk finding out which one you are. Russian Roulette.Gaming Future écrit: I really appreciate these videos, neuroscience is very interesting but can be confusing at time and these videos help me understandshitbag écrit: Thanks so much for these vids.? écrit: They are great if you suffer from some kind of stress i use xanaxChris Kuhn écrit: i just got diagnosed with GAD and this video really helped me. Thank you so much for your 2 minute videos!MugenTJ écrit: Ppl take this for anxiety and sleep issue? Then suffer hell for years to come? Sounds evil. What people should do is playing something calming to fall asleep (mine is science or natural science programs to listen to. Stimulating at first but over time became familiar and sleep inducing, more effective than music). Or whatever natural, you body will be tired and sleep. What the hell!svemirski putnici écrit: this shit's legal and mdma is not? well played, government.Ahmed Al_sayed écrit: Thanks bro .. ��NYCYTC écrit: Man I love popping xanny barz every night they smack ������Olekk ‘ écrit: I eat them every morning. You guys use them to sleep?Toon Link FTW écrit: Thank you! This really helped. I am taking a neurobiology course btw.mitch24d écrit: Soo your saying you really have no fucking clue how it works for sure but this is just what you found on Google and made a lil cartoon vid.kTearsky écrit: I don't need xanny to feel better -Billie EilishKhaotic Grumpy écrit: Bs that doctors refuse these to people who actually have real anxiety and instead give you placebo antidepressants all because of these kids abuseing and rapping about itno nickname écrit: Amazing explanationHawraa Hatem écrit: Thank u ����‍♀️H- Series écrit: Very helpful thank you so much sir for providing such a useful videoJay B écrit: Stay away from Benzos…that's all I can say. You'll regret it.Dave écrit: Man, benzos for sleep is a bad idea. Messes with your ability to get good rest like alcohol.SUDHARSAN écrit: Short and sweet sir !Dejan Markovic écrit: What if i take gaba supplements during the day and a bzd before sleep? Do they cancel each other out, or is the effect synergic? Thank you, already subscribed.Tim Langham écrit: Benzos are extremely effective by opening a neurotransmitter channel calcium ion ? which reduces a voltage which reduces a neuron's ability to fire, the allosteric effect. eticholanonalone also attaches to a neurotransmitter does this do the opposite or the same as a benzo? How much of this is known & if I want to understand how it works do I look towards neuro science or chemistryMimi Misse mîmįtā écrit: Thank youWethepeople Arefedup!!! écrit: And are hell to get off of !!!Callum Stanley écrit: Thanks for the video, helped with my assignment 🙂 YOU'RE THE BESTGavin Amish écrit: *lil xan has entered the chatAline Florence écrit: Thanks for the short and comprehensive video!Seadog95 écrit: Dont fuck with your gaba receptors. It will mess you upGarry Raymonds écrit: I feel anxious. Can't sleep without the sleeping pills or anti anxiety drugs. And to make things worse I think I’m getting addicted to them. How can I make myself feel better and sleep better?Peace597 écrit: Thank you!AllTheMani écrit: How can the GABA receptor be up regulated after benzo use?ゼロRe écrit: NICE:Dmandar Kumthekar écrit: Good. You are good teacher . good luckDiLLZGFX écrit: Thanks man, appreciate it !Alonso Quijano écrit: Dude this was extremely useful. Thanks for this, really.zainub farooqi écrit: Watching this after taking a tablet of Alprazolam (Xanax).
I was curious to know how it helps me fall asleep..I can Touch it? écrit: شتوا علوم شحال خرا يا تلاميذ واش جابنا لهنا باك 2016 علوم تجريبية :/Jack Lawler écrit: Maybe think about doing a 2 Minute Neuroscience on each of the Cranial Nerves? (Have a Neuroscience exam in 5 hours so these have been a great last minute update!) Keep up the great work!starvin marvin écrit: Never take benzos if you can avoid them. The withdrawal isn't worth it. Once the drug leaves your system it can take years to get back to normal. Just hit the 4 year mark of being off them and am still in hell.Konnapat chumdej écrit: Thanks ,blue lightMonica écrit: I never comment on Youtube videos, but I will do so now because your channel literally is sooo great. I appreciate your videos 😀Shaily Mehta écrit: Keep doing this. Doing neuroscience in medicine this term and your videos have saved me this term. You are a life saver <3Alaa Elorra écrit: This channel is a hidden gem. Not just any gem, like the most valuable and expensive gem. You guys deserve thousands of more subs and views. Maybe expand the channel to Biologically Challenged or Anatomically Challenged? idk hahaha i figure a less niche channel would attract more viewers.Shabit Hassan écrit: Ha just took a benzodiazepine and this popped up in my recommended listBoyana écrit: Thanks for the video, simple and easy to understand!Scofield écrit: Doesn't alcohol work in the same way?

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